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EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS

Year 2003, Volume: 16 Issue: 3, 173 - 178, 03.12.2016

Mehmet Koç Ahmet Toprak Hakan Tezcan Serhan Tuğlular İshak Çetin Özener Emel Akoğlu

Abstract

Objective: Control of hypertension (HT) can lead to regression of left ventricular mass index (LVMI) especially in the first year of renal transplantation. However, effect of better control of blood pressure (BP) on regression of LVMI in long-term renal transplant recipients is not known. In this study, we aimed to determine whether improved control of HT would decrease LVMI in renal transplant recipients or not.
Methods: Twenty-four nondiabetic renal
transplant recipients were included in the final analysis. Patients were categorized into group A (controlled-HT) and group B (uncontrolled-HT) according to their daytime blood pressure levels at the beginning of the study. Antihypertensive drug treatment of patients in group B was modified according to ambulatory blood pressure monitorization (ABPM) and clinical measurements. Echocardiographic examination was performed at baseline and at the end of 24 month.
Results: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) declined significantly (p<0.01) in parallel to increased use of angiotensin converting enzyme inhibitor (p<0.01) and LVMI remained unchanged in group B (113 ± 34 g / m2 vs 112 ± 29 g / m2 at baseline and at the end of 24 month,
respectively). Although SBP and DBP did not change significantly in group A, LVMI increased significantly (90 ±21 g / m2 to 107 ± 26 g / m2 at baseline and at the end of 24 month, respectively) in parallel to increase in serum creatinine (p<0.05) and decline in hemoglobin levels.
Conclusions: Our results suggest that control of BP is not sufficient either for the regression or maintenance of LVMI in long term renal transplant recipients. However, factors such as low hemoglobin level and worsening of renal function may play critical roles in the progression of LVMI even in patients with well-controlled BP.
Key Words: Renal transplantation, Left ventricular hypertrophy, Hypertension, Ambulatory blood pressure monitoring

References

  • Lind holm A, Albrechtsen D, Frodin L, Tufveson G, Persson TUI, Lundgren G. Ischemic heart disease-major cause of death and graft loss after renal transplantation in Scandinavia. Transplantation 1995; 60: 451- 457.
  • Rigatto C, Farfrey P, Foiey R, Tiegrijn C, Tribula C, Jeffery J. Congestive heart failure in renal transplant recipients: risk factors, outcomes, and relationship with ischemic heart disease. J Am Soc Hephrol 2002; 13: 1084-1090.
  • Silberberg JS, Barre PE, Prichard SS, Snidermann AD. Impact of left ventricular hypertrophy on survival of end-stage renal disease. Kidney Int 1989; 36: 286-290.
  • McGregor E, Jardine AG, Murray LS, et al. Preoperative échocardiographie abnormalities and adverse outcome following renal transplantation. Mephrol Dial Transplant 1998; 13: 1499-1505.
  • McGregor E, Stewart G, Rodger RS, Jardine
  • AG. Early échocardiographie changes and
  • Mehmet Koç, et al.
  • survival following renal transplantation. Hephrol Dial Transplant 2000; 15: 95-98.
  • Foley RH, Farfrey FS, Harnett JD, Kent OF1, Murray DC, Barre FE. Impact of hypertension on cardiomyopathy, morbidity and mortality in end stage renal disease. Kidney Int 1996; 49: 1379-1385.
  • Huting J. Course of left ventricular hypertrophy and function in end-stage renal disease after renal transplantation. Am J Cardiol 1992; 70: 1481-1484.
  • Farfrey FS, Harnett JD, Foley RH, et al. Impact of renal transplantation on uremic cardiomyopathy. Transplantation 1995; 60: 908-914.
  • Midtvedt K, Ihlen H, Hartmann A, et al.
  • Reduction of left ventricular mass by lisinopril and nifedipine in hypertensive renal transplant recipients: a prospective
  • randomised double-blind study.
  • Transplantation 2001; 72: 107-111.
  • Rigatto C, Foley RH, Kent QM, Quttmann R, Farfrey FS. Long-term changes in left ventricular hypertrophy after renal transplantation. Transplantation 2000; 70: 570-575.
  • Koc M, Toprak A, Ozener IC, et al. QT dispersion in renal transplant recipients. Hephron 2002; 91: 250-254.
  • The Sixth Report of the Joint national Committee on Prevention, Detection, Evaluation and Treatment of High Blood Fressure. Arch of Int Med, 1997; 157: 2413- 2448.
  • Burt VL, Cutler JA, Higgins M,, et al. Trends in the prevalence, awareness, treatment, and control of hypertension in the adult US population. Data from the health examination surveys, I960 to 1991. Hypertension 1995; 26: 60-69.
  • Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of échocardiographie measurements. Circulation 1978; 58: 1072-1083.
  • Devereux RB, Alonso DR, Lutas EM, et al.
  • Echocardiographie assessment of left ventricular hypertrophy: comparison to
  • necropsy findings. Am J Cardiol 1986; 57: 450-458.
  • De Lima JJ, Vieira ML, Viviani LF, et al. Longterm impact of renal transplantation on carotid artery properties and on ventricular hypertrophy in end-stage renal failure patients. Hephrol Dial Transplant 2002: 17: 645-651.
  • I 7. Fernandez-Vega F, Tejada F, Baltar J, Laures A, Oomez E, Alvarez J. Ambulatoiy blood pressure after renal transplantation. Hephrol Dial Transplant 2001 ; 16 (Suppl I): 110-113.
  • Toprak A, Koc M, Tezcan H, Ozener 1C, Oktay A, Akoglu E. Highttime blood pressure load is associated with higher left ventricular mass index in renal transplant recipients. J Hum Hypertens 2003; I 7: 239-244.
  • Foley RH, Farfrey FS, Kent QM, tlarnett JD, Murray DC, Barre FE. Long-term evolution of cardiomyopathy in dialysis patients. Kidney Int 1998: 54: ¡720-1725.

Year 2003, Volume: 16 Issue: 3, 173 - 178, 03.12.2016

Mehmet Koç Ahmet Toprak Hakan Tezcan Serhan Tuğlular İshak Çetin Özener Emel Akoğlu

Abstract

References

  • Lind holm A, Albrechtsen D, Frodin L, Tufveson G, Persson TUI, Lundgren G. Ischemic heart disease-major cause of death and graft loss after renal transplantation in Scandinavia. Transplantation 1995; 60: 451- 457.
  • Rigatto C, Farfrey P, Foiey R, Tiegrijn C, Tribula C, Jeffery J. Congestive heart failure in renal transplant recipients: risk factors, outcomes, and relationship with ischemic heart disease. J Am Soc Hephrol 2002; 13: 1084-1090.
  • Silberberg JS, Barre PE, Prichard SS, Snidermann AD. Impact of left ventricular hypertrophy on survival of end-stage renal disease. Kidney Int 1989; 36: 286-290.
  • McGregor E, Jardine AG, Murray LS, et al. Preoperative échocardiographie abnormalities and adverse outcome following renal transplantation. Mephrol Dial Transplant 1998; 13: 1499-1505.
  • McGregor E, Stewart G, Rodger RS, Jardine
  • AG. Early échocardiographie changes and
  • Mehmet Koç, et al.
  • survival following renal transplantation. Hephrol Dial Transplant 2000; 15: 95-98.
  • Foley RH, Farfrey FS, Harnett JD, Kent OF1, Murray DC, Barre FE. Impact of hypertension on cardiomyopathy, morbidity and mortality in end stage renal disease. Kidney Int 1996; 49: 1379-1385.
  • Huting J. Course of left ventricular hypertrophy and function in end-stage renal disease after renal transplantation. Am J Cardiol 1992; 70: 1481-1484.
  • Farfrey FS, Harnett JD, Foley RH, et al. Impact of renal transplantation on uremic cardiomyopathy. Transplantation 1995; 60: 908-914.
  • Midtvedt K, Ihlen H, Hartmann A, et al.
  • Reduction of left ventricular mass by lisinopril and nifedipine in hypertensive renal transplant recipients: a prospective
  • randomised double-blind study.
  • Transplantation 2001; 72: 107-111.
  • Rigatto C, Foley RH, Kent QM, Quttmann R, Farfrey FS. Long-term changes in left ventricular hypertrophy after renal transplantation. Transplantation 2000; 70: 570-575.
  • Koc M, Toprak A, Ozener IC, et al. QT dispersion in renal transplant recipients. Hephron 2002; 91: 250-254.
  • The Sixth Report of the Joint national Committee on Prevention, Detection, Evaluation and Treatment of High Blood Fressure. Arch of Int Med, 1997; 157: 2413- 2448.
  • Burt VL, Cutler JA, Higgins M,, et al. Trends in the prevalence, awareness, treatment, and control of hypertension in the adult US population. Data from the health examination surveys, I960 to 1991. Hypertension 1995; 26: 60-69.
  • Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of échocardiographie measurements. Circulation 1978; 58: 1072-1083.
  • Devereux RB, Alonso DR, Lutas EM, et al.
  • Echocardiographie assessment of left ventricular hypertrophy: comparison to
  • necropsy findings. Am J Cardiol 1986; 57: 450-458.
  • De Lima JJ, Vieira ML, Viviani LF, et al. Longterm impact of renal transplantation on carotid artery properties and on ventricular hypertrophy in end-stage renal failure patients. Hephrol Dial Transplant 2002: 17: 645-651.
  • I 7. Fernandez-Vega F, Tejada F, Baltar J, Laures A, Oomez E, Alvarez J. Ambulatoiy blood pressure after renal transplantation. Hephrol Dial Transplant 2001 ; 16 (Suppl I): 110-113.
  • Toprak A, Koc M, Tezcan H, Ozener 1C, Oktay A, Akoglu E. Highttime blood pressure load is associated with higher left ventricular mass index in renal transplant recipients. J Hum Hypertens 2003; I 7: 239-244.
  • Foley RH, Farfrey FS, Kent QM, tlarnett JD, Murray DC, Barre FE. Long-term evolution of cardiomyopathy in dialysis patients. Kidney Int 1998: 54: ¡720-1725.
There are 27 citations in total.

Details

Journal Section Original Research
Authors

Mehmet Koç

Ahmet Toprak This is me

Hakan Tezcan This is me

Serhan Tuğlular This is me

İshak Çetin Özener This is me

Emel Akoğlu This is me

Publication Date December 3, 2016
Published in Issue Year 2003 Volume: 16 Issue: 3

Cite

APA Koç, M., Toprak, A., Tezcan, H., Tuğlular, S., et al. (2016). EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS. Marmara Medical Journal, 16(3), 173-178.
AMA Koç M, Toprak A, Tezcan H, Tuğlular S, Özener İÇ, Akoğlu E. EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS. Marmara Med J. March 2016;16(3):173-178.
Chicago Koç, Mehmet, Ahmet Toprak, Hakan Tezcan, Serhan Tuğlular, İshak Çetin Özener, and Emel Akoğlu. “EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS”. Marmara Medical Journal 16, no. 3 (March 2016): 173-78.
EndNote Koç M, Toprak A, Tezcan H, Tuğlular S, Özener İÇ, Akoğlu E (March 1, 2016) EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS. Marmara Medical Journal 16 3 173–178.
IEEE M. Koç, A. Toprak, H. Tezcan, S. Tuğlular, İ. Ç. Özener, and E. Akoğlu, “EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS”, Marmara Med J, vol. 16, no. 3, pp. 173–178, 2016.
ISNAD Koç, Mehmet et al. “EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS”. Marmara Medical Journal 16/3 (March 2016), 173-178.
JAMA Koç M, Toprak A, Tezcan H, Tuğlular S, Özener İÇ, Akoğlu E. EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS. Marmara Med J. 2016;16:173–178.
MLA Koç, Mehmet et al. “EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS”. Marmara Medical Journal, vol. 16, no. 3, 2016, pp. 173-8.
Vancouver Koç M, Toprak A, Tezcan H, Tuğlular S, Özener İÇ, Akoğlu E. EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS. Marmara Med J. 2016;16(3):173-8.